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Although the findings are not always consistent, changes in the brainstem have been very common, especially structural changes, mainly a decrease in grey or white matter volume in patients, often pronounced in relation to the symptom burden of fatigue, pain and autonomic symptoms

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Statements Author contributions TH: Supervision, Visualization, Writing original draft, Formal analysis, Software, Data curation, Funding acquisition, Methodology, Validation, Conceptualization, Resources, Investigation, Project administration, Writing review & editing